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KMID : 0383820100680010022
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Tuberculosis and Respiratory Diseases
2010 Volume.68 No. 1 p.22 ~ p.28
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Immunohistochemical Expression and Prognostic Value of VEGF, HIF-1α, EGFR in Non-Small Cell Lung Cancer
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Kim Myung-Sook
Park Sung-Hak
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Abstract
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Background: Vascular endothelial growth factor (VEGF) is a potent mediator of angiogenesis. VEGF production is regulated by HIF-1α and EGFR. This study examined the relationship between the clinicopathological factors and VEGF, HIF-1α and EGFR protein overexpression, and evaluated their prognostic value in patients with a surgically resected non-small cell lung cancer (NSCLC).
Materials and Methods : Patients who underwent a surgical resection at Kangnam St. Mary’s hospital were reviewed retrospectively. The core biopsy samples from 54 patients with NSCLC were assembled on a tissue microarray (TMA), and immunohistochemical staining for the VEGF, HIF-1α and EGFR proteins was performed. The overexpression of these proteins was evaluated in relation to age, gender, histology and staging by univariate analysis. The clinicopathological prognostic factors were analyzed.
Results: Multivariate analysis performed by Cox regression (odds ratio 2.8, 95% CI 1.0∼8.2, p=0.046) revealed HIF-1α overexpression to be an unfavorable factor. There was no correlation between the overexpression of these proteins and the clinicopathological factors. VEGF showed a positive relationship with EGFR, but there was no statistical significance [p(χ2)=0.06].
Conclusion: HIF-1α overexpression predicts shorter survival in patients with a surgically resected NSCLC. Therefore, HIF-1α may be a poor prognostic factor in NSCLC.
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KEYWORD
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Carcinoma, Non-Small-Cell Lung, Immunohistochemistry, Prognosis
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